Antiamnesic Activity of Guggul Extract on Scopolamine Induced Amnesia in Mice

Objective of this study was to evaluate Guggul extract for the treatment of Alzheimer’s disease using scopolamine induced amnesia in mice on Morris water maze. Guggul extract (50mg/kg) was administered orally for fifteen successive days followed by Scopolamine (0.4 mg/kg i.p.) from 15 th to 18 th day in mice. Morris water maze was employed to evaluate learning and memory using parameter like Escape Latency Time (ELT), Time Spent in Target Quadrant (TSTQ) and determination of brain Acetylcholinesterase level. Scopolamine was used to induce amnesia in mice and the activity was compared with standard drug Piracetam. Guggul extract significantly improved learning and memory in mice and reversed the scopolamine induced amnesia. Guggul extract when co administered with Piracetam (200mg/kg) has shown synergistic activity. Guggul extract is a known hypolipidemic agent and has shown excellent activity in scopolamine induced amnesia when given orally for 15 successive days in mice. It has shown synergistic effect with Piracetam and further detailed studies are required to exploit Guggul extract as new therapeutic agents for antialzheimer’s disease.